Functional Annotation and Epitope Prediction of Hypothetical Proteins of Mycobacterium tuberculosis H37Rv: An Immunoinformatics Approach
نویسندگان
چکیده
منابع مشابه
HYPOTHETICAL PROTEINS OF MYCOBACTERIUM TUBERCULOSIS H37Rv AS DRUG TARGETS
Hypothetical proteins often with unknown functions . Mycobacterium tuberculosis H37Rv has a very large number of such proteins , which can be exploited as drug target as the bacterium became more virulent with developing antibiotic resistance to first line and second line of drugs . Some hypothetical proteins (290 proteins) were studied from different aspects related to find the druggable prote...
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High-throughput biology technologies have yielded complete genome sequences and functional genomics data for several organisms, including crucial microbial pathogens of humans, animals and plants. However, up to 50% of genes within a genome are often labeled "unknown", "uncharacterized" or "hypothetical", limiting our understanding of virulence and pathogenicity of these organisms. Even though ...
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Original genome annotations need to be regularly updated if the information they contain is to remain accurate and relevant. Here the complete re-annotation of the genome sequence of Mycobacterium tuberculosis strain H37Rv is presented almost 4 years after the first submission. Eighty-two new protein-coding sequences (CDS) have been included and 22 of these have a predicted function. The majori...
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ژورنال
عنوان ژورنال: Journal of Bioengineering & Biomedical Science
سال: 2016
ISSN: 2155-9538
DOI: 10.4172/2155-9538.1000196